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  1. josh heller

    i wanted to respond to this comment in regard to mdpv’s addiction potential. “Seems like it but it’s really new so we don’t know HOW and WHY yet.”

    according to the biochemists at pubmed MDPV inhibits catecholamine (dopamine, epinephrine, norepinephrine, serotonin) transport (also known as reuptake inhibition).
    the majority of the effect happens with dopamine and norepinephrine. more similar to cocaine than amphetamines which have strong effects on serotonin as well.
    dopamine is of course a factor in motivation, reward and addiction for many substances

    here is also a study which involves a bit more reinforcement of mechanism with a comparison to methamphetamine
    it does not appear that follow up is offered on results of methamphetamine comparison in the abstract

    i hope this will give people a better picture.

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